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BPA is identified as an endocrine-disrupting chemical that deteriorates the physiological function of the hormones of the male reproductive system. Bisphenol F (BPF), bisphenol S (BPS), and bisphenol AF (BPAF) are actively explored as substitutes for BPA and are known as BPA analogues in most manufacturing industries. These analogues may demonstrate the same adverse effects as BPA on the male reproductive system; however, toxicological data explaining the male reproductive hormones’ physiological functions are still limited. Hence, this mini-review discusses the effects of BPA and its analogues on the physiological functions of hormones in the male reproductive system, focusing on the hypothalamus-pituitary-gonad (HPG) axis, steroidogenesis, and spermatogenesis outcomes. The BPA analogues mainly show a similar negative effect on the hormones’ physiological functions, proven by alterations in the HPG axis and steroidogenesis via activation of the aromatase activity and reduction of spermatogenesis outcomes when compared to BPA in in vitro and in vivo studies. Human biomonitoring studies also provide significant adverse effects on the physiological functions of hormones in the male reproductive system. In conclusion, BPA and its analogues deteriorate the physiological functions of hormones in the male reproductive system as per in vitro, in vivo, and human biomonitoring studies.

40層細(xì)胞工廠

BPA 被認(rèn)為是一種內(nèi)分泌干擾化學(xué)物質(zhì)，會(huì)破壞男性生殖系統(tǒng)激素的生理功能。雙酚 F (BPF)、雙酚 S (BPS) 和雙酚 AF (BPAF) 被積極探索作為 BPA 的替代品，在大多數(shù)制造業(yè)中被稱為 BPA 類似物。這些類似物可能表現(xiàn)出與雙酚 A 對(duì)男性生殖系統(tǒng)相同的不利影響；然而，解釋雄性生殖激素生理功能的毒理學(xué)數(shù)據(jù)仍然有限。因此，這篇小型綜述討論了 BPA 及其類似物對(duì)男性生殖系統(tǒng)激素生理功能的影響，重點(diǎn)關(guān)注下丘腦-垂體-性腺 (HPG) 軸、類固醇生成和精子生成結(jié)果。在體外和體內(nèi)研究中，與 BPA 相比，BPA 類似物主要對(duì)激素的生理功能顯示出類似的負(fù)面影響，這證明了 HPG 軸的改變和類固醇生成通過芳香酶活性的激活和精子發(fā)生結(jié)果的減少。人體生物監(jiān)測(cè)研究還對(duì)男性生殖系統(tǒng)中激素的生理功能產(chǎn)生了顯著的不利影響。總之，根據(jù)體外、體內(nèi)和人體生物監(jiān)測(cè)研究，BPA 及其類似物會(huì)降低男性生殖系統(tǒng)中激素的生理功能。人體生物監(jiān)測(cè)研究還對(duì)男性生殖系統(tǒng)中激素的生理功能產(chǎn)生了顯著的不利影響。總之，根據(jù)體外、體內(nèi)和人體生物監(jiān)測(cè)研究，BPA 及其類似物會(huì)降低男性生殖系統(tǒng)中激素的生理功能。人體生物監(jiān)測(cè)研究還對(duì)男性生殖系統(tǒng)中激素的生理功能產(chǎn)生了顯著的不利影響。總之，根據(jù)體外、體內(nèi)和人體生物監(jiān)測(cè)研究，BPA 及其類似物會(huì)降低男性生殖系統(tǒng)中激素的生理功能。

高效細(xì)胞搖瓶5L

In conclusion, BPA and its analogues may be an additional risk factor to consider because they disrupt the hormonal physiological functions of the male reproductive system. The results of the experimental studies mostly point to BPA and its analogues having the ability to disrupt the endocrine system, resulting in HPG axis disturbances and activation of the steroidogenesis alternative pathway, which is why more experimental and epidemiological research will be required to establish the scale of the effects caused by these chemicals in large populations and its molecular mechanism to a better understanding of the connection between HPG axis, steroidogenesis, and spermatogenesis outcomes. Despite the fact that many nations have adopted policies to limit exposure to BPA and its analogues in their populations, epidemiological research on humans imply that the same abnormalities seen in experimental studies on animals may be detected. Understanding the association between BPA and its analogues and physiological hormonal activities can aid in raising public awareness and implementing public health campaigns to prevent exposure to these compounds, particularly among those attempting to conceive and elderly populations.

總之，雙酚 A 及其類似物可能是一個(gè)需要考慮的額外風(fēng)險(xiǎn)因素，因?yàn)樗鼈儠?huì)擾亂男性生殖系統(tǒng)的激素生理功能。實(shí)驗(yàn)研究的結(jié)果大多指向 BPA 及其類似物具有破壞內(nèi)分泌系統(tǒng)的能力，導(dǎo)致 HPG 軸紊亂和類固醇生成替代途徑的激活，這就是為什么需要更多的實(shí)驗(yàn)和流行病學(xué)研究來建立規(guī)模這些化學(xué)物質(zhì)在大量人群中引起的影響及其分子機(jī)制，以更好地了解 HPG 軸、類固醇生成和精子生成結(jié)果之間的聯(lián)系。盡管許多國家已采取政策限制其人群接觸雙酚 A 及其類似物，對(duì)人類的流行病學(xué)研究表明，可能會(huì)檢測(cè)到動(dòng)物實(shí)驗(yàn)研究中所見的相同異常。了解雙酚 A 及其類似物與生理荷爾蒙活動(dòng)之間的關(guān)聯(lián)，有助于提高公眾意識(shí)和開展公共衛(wèi)生運(yùn)動(dòng)，以防止接觸這些化合物，尤其是那些懷孕的人和老年人。

 
細(xì)胞轉(zhuǎn)瓶2L

關(guān)鍵詞：Aromatase, bisphenol F,bisphenol AF,bisphenol S,HPG axis,steroidogenesis,芳香化酶,雙酚 F,雙酚AF,雙酚S,HPG 軸,類固醇生成,

來源: MDPI  https://www.mdpi.com/2227-9059/9/11/1744/htm